Mismatch repair
| PAG Title | Mismatch repair |
| PAG ID | WAG000204 |
| Type | P |
| Source Link |  KEGG |
| Publication Reference | NA |
| PAG Description | D mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects D mismatches generated during D replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombition and was recently shown to play a role in D damage sigling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 5,817 |
| Information Content | Rich |
| Other IDs | hsa03430 |
| Base PAG ID | WAG000204 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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